LC_PH0482B
737
HPLC CHROMATOGRAMS |
PHARMACEUTICAL
Potent ial Genotoxic Impur i t ies, Analgesics
Potential Genotoxic Impurities
Ultra II® Aromax
Peak List
M/Z*
1. ethyl benzenesulfonate
204
2. isopropyl toluenesulfonate
232
3.
n
-propyl toluenesulfonate
232
4.
n
-butyl toluenesulfonate
246
*All M/Z are [M+NH
4
]
+
Sample:
Inj.:
100µL
Conc.:
10ng/mL each PGI in 1mg/mL dorzolamide
Sample diluent: mobile phase
Column:
Ultra II
®
Aromax
Cat.#:
9607312
Dimensions:
100mm x 2.1mm
Particle size:
3µm
Pore size:
100Å
Conditions:
Instrument:
Agilent 1100
Mobile phase:
A: 0.2% ammonium acetate in water
B: 0.2% ammonium acetate in methanol
Flow:
0.3mL/min.
Temp.:
ambient
Det.:
LECO TOF-MS
NEW!
Hydroxybenzoic Acids on Ultra Aqueous C18
LC_PH0400
1. 3,5-dihydroxybenzoic acid
2. 2,5-dihydroxybenzoic acid
3. 4-hydroxybenzoic acid
4. 3-hydroxybenzoic acid
5. 2,4-dihydroxybenzoic acid
6. benzoic acid
7. salicylic acid
Sample:
Inj.:
5µL
Conc.:
50µg/mL each component
Sample diluent: mobile phase
Column:
Ultra Aqueous C18
Cat.#:
9178565
Dimensions:
150mm x 4.6mm
Particle size:
5µm
Pore size:
100Å
Conditions:
Mobile phase:
A: 20mM potassium phosphate (pH 2.5);
B: acetonitrile
Time
(min.)
%B
0.00 20
5.00 50
10.00 50
Flow:
1.0mL/min.
Temp.:
ambient
Det.:
UV @ 210nm
Website :
E-mail :
TelNo : 03 9762 2034 . . . in AUSTRALIA
Mar 2011
