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EuropeanPharmocopoeia/ICHClass1Mix
benzene
2µg/mL 1,1-dichloroethene
8µg/mL
carbon tetrachloride
4
1,1,1-trichloroethane 1500
1,2-dichloroethane
5
Prepared inwater:dimethylsulfoxide 90:10, 1mL/ampul
Ea.: 36228
5-pk.: 36228-510
10-pk.: 36328
EuropeanPharmocopoeia/ICHClass2MixA
chlorobenzene
360µg/mL N,N-dimethylformamide 880µg/mL
cyclohexane
3,880
toluene
890
cis
-1,2-dichloroethene 1,870
1,1,2-trichloroethene
80
dichloromethane
600
m
-xylene
1,302
ethylbenzene
369
o
-xylene
195
hexane
290
p
-xylene
304
methylcyclohexane
1,180
Prepared inwater:dimethylsulfoxide 90:10, 1mL/ampul
Ea.: 36229
5-pk.: 36229-510
10-pk.: 36329
Rtx
®
-1301Columns
Length
ID
df (µm)
cat.#/price
30m
0.32mm
1.5
30m
0.53mm
3.0
Stabilwax
®
Columns
Length
ID
df (µm)
cat.#/price
30m
0.32mm
0.25
30m
0.53mm
0.50
Product Listing
EuropeanPharmocopoeia/ICHClass2MixB
acetonitrile
410µg/mL 2-hexanone
50µg/mL
chloroform
60
methanol
3,000
1,2-dimethoxyethane
100
nitromethane
50
N,N-dimethylacetamide 1,090
pyridine
200
1,4-dioxane
380
1,2,3,4-tetrahydronaphthalene (tetraline)
100
Prepared inwater:dimethylsulfoxide 90:10, 1mL/ampul
Ea.: 36230
5-pk.: 36230-510
10-pk.: 36330
EuropeanPharmocopoeia/ICHClass2MixC
2-ethoxyethanol
160µg/mL N-methylpyrrolidone 4,840µg/mL
ethylene glycol
620
sulfolane
160
formamide
220
2-methoxyethanol
50
Prepared inwater, 1mL/ampul
Ea.: 36231
5-pk.: 36231-510
10-pk.: 36331
Figure 2:
The Stabilwax
®
columnmakes an excellent confirmation column for the analysis of residual solvents.
1. methanol
2. 1,1-dichloroethene
3. acetonitrile
4. methylene chloride (dichloromethane)
5. hexane (C6)
6. cis-1,2-dichloroethene
7. nitromethane
8. chloroform
9. cyclohexane
10. 1,1,1-trichloroethane
11. carbon tetrachloride
12. benzene
13. 1,2-dimethoxyethane
14. 1,2-dichloroethane
15. trichloroethylene (1,1,2-trichlorethene)
16. methylcyclohexane
17. 1,4-dioxane
18. pyridine
19. toluene
20. 2-hexanone
21. chlorobenzene
22. DMF
23. ethylbenzene
24.
m
-xylene
25.
p
-xylene
26.
o
-xylene
27. N,N-dimethylacetamide
28. 1,2,3,4-tetrahydronaphthalene
10,11
5,9
2 4 6 8 10 12 14 16 18 20 22 24 26 28 30
16
2
4 13
12
6,15
3
8
19
17 14
20
23
25 24
7
18,26
21
22
27
28
30m x .53mm ID x 0.5µmStabilwax
®
(cat.# 10640-126)
Headspace injection of 28Class 1 and 2 residual
solvents for pharmaceutical processing. Prepared at
the regulatory limit concentration. Samples shaken
and heated at 80°C for 15minutes, 1mL headspace
injection.
Oven temp.:
50°C (hold20min.) to165°C@
6°C/min. (hold20min.)
Inj./det. temp.:
200°C/250°C
FID sensitivity:
1.1x10
-11
AFS
Carrier gas:
hydrogen@35cm/sec.
Split ratio:
2:1
10624
10640
16069
16085
