CLINICAL/FORENSICS
25
Cold & Sinus Medications
GC
GC
Cold&SinusMedications
Cold and sinus medications can be analyzed for
phenylpropanolamine using a simple extraction
procedure followed by GC analysis. An Rtx
®
-5
Amine or Rtx
®
-35Amine columnprovides excel-
lent resolution of all the compounds commonly
found
in
most
cold
medications.
Phenylpropanolamine is separated easily from
the other compounds. All target analytes exhibit
good peak shape, even when in the free base
form.Additionally, theanalysis is complete in less
than15minutes,whichallowsquick turn-around
ofmultiple samples.
1. phenylpropanolamine
2. phenylephrine
3. guaifenesin
4. pheniramine
5. phenyltoloxamine
6. chlorpheniramine
7. brompheniramine
8. dextromethorphan
9. pyrilamine
10. codeine
11. hydrocodone
30m, 0.53mm ID, 1.0µmRtx
®
-5 Amine (cat.# 12355)
Oven temp.:
175°C to 280°C@ 10°/min. (hold 5.5min.)
Inj./det. temp.:
250°C/280°C
Carrier gas:
helium
Linear velocity:
40cm/sec.
Sample size:
1µL
Split vent flow:
88mL/min.
Split ratio:
20:1
1
2
3
4
5
6
7
8
9
10
11
min.
2
4
6
8
10
12
14
16
ColdMedications (Underivatized)
Rtx®-5Amine
GC_PH00469
Rtx
®
-35 Amine 30m, 0.25mm ID, 0.50µm (cat.# 11338)
1.0µL split injection of underivatized coldmedicines
Conc.:
1000ng/µL
Inj. temp:
250°C
Carrier gas:
helium
Linear velocity:
30cm/sec.
Oven temp.:
250°C to 300°C@ 7°C/min. (hold 7min.)
Det.:
MSD
Scan range:
40–450amu
Ionization:
EI
Mode:
scan
ColdMedications (Underivatized)
Rtx®-35Amine
1. guaifenesin
2. pheniramine
3. phenyltoloxamine
4. chlorpheniramine
5. brompheniramine
6. dextromethorphan
7. pyrilamine
8. triprolidine
9. codeine
10. hydrocodone
GC_PH00575
free
literature
GCAnalysis of Phenylpropanolamine in ColdMedications,
Using an Rtx
®
-5Amine Column
lit. cat.# 59339
Call Restek at 800-356-1688 or 814-353-1300, ext. 5, or contact
your Restek representative, to request your free copy!
