CLINICAL/FORENSICS
19
Analgesic Formulations
HPLC
Acetaminophen (Analgesic),Pseudoephedrine
(Decongestant), andCaffeine (Stimulant)
Allure™Basix
1
Peak List:
1. sample solvent
2. caffeine
3. acetaminophen
4. pseudoephedrine
Sample:
Inj.:
5µL
Conc.:
100µg/mL
Solvent:
mobile phase
Column:
Allure
™
Basix
Cat.#:
9161565
Dimensions:
150 x 4.6mm
Particle size:
5µm
Pore size:
60Å
Conditions:
Mobile phase:
10mM ammonium acetate,
pH 6.9: methanol (75:25, v/v)
Flow:
1.0mL/min.
Temp.:
25°C
Det.:
UV@ 210nm
2
3
4
0
2
4
6
8
10
12 min.
LC_0097
Guaifenesin (Expectorant/Antitussive)and
Codeine (NarcoticAnalgesic)
UltraPhenyl
1
Peak List:
Conc. (µg/mL)
1. codeine
825
2. guaifenesin
375
Sample:
Inj.:
5µL
Solvent:
methanol:water (50:50)
Column:
Ultra Phenyl
Cat.#:
9105565
Dimensions:
150 x 4.6mm
Particle size:
5µm
Pore size:
100Å
Conditions:
Mobile phase:
10mM ammonium
formate, pH 2.5:
acetonitrile
(80:20, v/v)
Flow rate:
1.2mL/min.
Temp.:
25°C
Det.:
UV@ 280nm
0
1
2
3
4
5
6 min.
LC_0088
2
HPLC
Ibuprofen (Analgesic)andPseudoephedrine
(Decongestant)
Allure™Basix
Sample:
Inj.:
5µL
Conc.:
200µg/mL
Solvent:
mobile phase
Column:
Allure
™
Basix
Cat.#:
9161565
Dimensions:
150 x 4.6mm
Particle size:
5µm
Pore size:
60Å
Conditions:
Mobile phase:
10mM ammonium
acetate, pH 6.9:
methanol (75:25, v/v)
Flow:
1.0mL/min.
Temp.:
25°C
Det.:
UV@ 210nm
Peak List:
1. uracil
2. ibuprofen
3. pseudoephedrine
1
2
3
LC_0098
0
2
4
6
8
10
12
14 min.
free
literature
HPLCColumns&Accessories
(catalog)
lit. cat.# 59241B
Analysis of Narcotics&Narcotic/AcetaminophenAdmixtures:
What to doWhenCompendiumMethodsDon’tWork
lit. cat.# 59453
Call Restek at 800-356-1688 or 814-353-1300, ext. 5, or contact
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