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In This Issue
Connections. 2–3
Hot Topics. 4–5
Technical Articles. 6–19
The Effects of LC Particle Choice on Column
Performance: Fully Porous Particles (FPP) vs.
Superficially Porous Particles (SPP) . 6–7
Helium to Hydrogen: Optimize for Speed or Match
Your Original Compound Retention Times With
Restek’s EZGC® Method Translator. 8–9
How to Choose a GC Inlet Liner: Simplify Selection
Based on Injection Type. . . . . . . . . . . 10–11
Optimizing an Agilent-Style Splitless Inlet for
Concurrent Solvent Recondensation–Large
Volume Splitless Injection (CSR-LVSI). 12–13
New GC Method for Polycyclic Aromatic Compounds
in Yerba Mate Tea Combines Simplified Prep and
Improved Accuracy for EFSA PAH4 and EFSA PAH8
Compounds. 14–15
Improve Sample Throughput for LC‐MS/MS
Analysis of Vitamin D Metabolites in Plasma
With a New Raptor™ ARC-18 Column . 16–17
High-Throughput Cannabis Potency Methods for
LC and GC Produce Results Quickly Without the
Cost of New Equipment. 18–19
Virtually Particle-Free Rt®-Silica BOND Columns
Provide Reliable PLOT Column PerformanceWith
Less Downtime for Maintenance. 20–21
The Role of Selectivity in Liquid Chromatography
Method Development. 22–23
About Restek Corporation
Chromatography is what Restek does, and chromatography is
who we are. We are an independent, international, and diverse
team of employee-owners not bound to a specific brand of
instrument or geographic region. We live and breathe phase
chemistry, peak separations, resolution, and inertness because
while chromatography may be a necessary tool in your busi-
ness, it is our business. And it is a business that we directly serve
across 100+ countries and six continents with unrivaled Plus 1
service, applications, and expertise.
From LC and GC columns to sample prep, reference standards
to accessories, Restek is your first and best choice for chro-
matography.
Restek is Pure Chromatography.
Patents and Trademarks
Restek® patents and trademarks are the property of Restek Corpora-
tion. (See for full list.) Other
trademarks appearing in Restek® literature or on its website are the
property of their respective owners. The Restek® registered trade-
marks used here are registered in the United States and may also be
registered in other countries.
Reflections from the Bench
You Have Opinions... andWe Want Them
We chemists are an opinionated bunch, so the odds are good that you have
some thoughts about the Restek® Advantage. Love it? Hate it? Want to see
something different in the next issue? Maybe you have a response to one of our
technical articles? Whatever you have to say, let’s hear it! E-mail your comments to
and you may even see them in an upcoming issue.
So... method development! Exciting? Scary? Frustrating?
Rewarding?
How about “all of the above”? I’ve experienced all four—and
more—over my years in R&D and product marketing.
Method development is the thrill of creation. The challenge of
problem solving. The excitement of discovery. But, let’s face it:
sometimes it’s the frustration of just wanting to get the job done.
It’s the reality that something is not working, and the spotlight is
on you to fix it.
However you look at it, method development comes with a great deal of responsibility.
Many of us are developing methods for very important applications in our own industries.
So, building an accurate, precise, and robust method that doesn’t require a third arm and a
lucky rabbit’s foot is vital. I appreciate this even more now as the supervisor of our Quality
Control Department, where we develop our own methods to make sure Restek® products
perform as you need them to—every time you use them.
Whether you are in the emerging field of medical cannabis testing (see page 18), on the
hunt for Vitamin D in blood (see page 16), or looking for some ways to continue improving
methods you already have (look inside for articles on choosing LC silica particles, GC car-
rier gasses, and GC inlet liners), you should find something in this issue of the Advantage
to make your job easier.
When I came to Restek eight years ago, I found that my method development game
progressed in leaps and bounds by virtue of being surrounded by skilled colleagues who
both knew and loved the challenge of creating outstanding chromatographic methods.
They were sincerely invested in my success, and let me tell you, having coworkers like that
is awesome.
And as much as they were willing to help me then, my colleagues and I are eager to lend
you a hand now. Chromatography is what we do, and we love sharing it!
Best regards,
Scott Grossman
Quality Control Technical Supervisor
Restek® Connections
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