ADV06-15_1-412

•

2007 vol. 2

Clinical/Forensics/Toxicology

pared to base-deactivated or Siltek® treated liners,

due to the acidic nature of the undeactivated glass

surface or to a small but influential number of

residual acidic sites remaining on the intermediate

polarity deactivated surface.

Because the undeactivated liners and intermediate

polarity treated liners exhibited either low mean

response or high variation, we reanalyzed the data,

excluding these treatments and comparing the

remaining data (for base-deactivated liners and

Siltek® treated liners) for responses and repro-

ducibility. As shown by the examples in Figure 2,

base-deactivated liners and Siltek® treated liners

performed equally well for cocaine, but the base-

deactivated liners yielded the best responses and

reproducibility for PCP. Ultimately, a base-deacti-

vated liner would give the best overall perform-

ance. Figure 3 shows the linearity plots for all ana-

lyzed drugs, obtained using a base-deactivated

liner and an Rtx®-5Amine column. Low %RSD

values for ketamine (3%), phencyclidine (2%),

methadone (2%), cocaine (3%), codeine (5%),

and alprazolam (12%) confirm the reproducibility

of data obtained from this combination.

Because nitrogen- and oxygen-containing drugs

react with silanol groups on glass surfaces, it is

important to use properly deactivated glass inlet

liners when analyzing these compounds by GC.

This work demonstrates that a base-deactivated

inlet liner, used in combination with a base-deac-

tivated column, produces high and reproducible

responses for basic drugs.

new

products

For our new reference standards for drugs of abuse, please go to our website

www.restek.com/standards

Base-Deactivated Inlet Liners

For base-deactivated inlet liners, add the corresponding suffix number to the liner catalog number.

qty.

Base-Deactivated Liner

Base-Deactivated Liner w/ Base-Deactivated Wool

each

-210.1

$14

addl. cost

-211.1

$17

addl. cost

5-pk.

-210.5

$45

addl. cost

-211.5

$60

addl. cost

25-pk.

-210.25

$145

addl. cost

-211.25

$180

addl. cost

Base-DeactivatedWool

Ideal for amines and other basic compounds.

Description

qty.

cat.#

price

Base-Deactivated Wool

10 grams

20999

$54

Base Deactivated Inlet Liners for Basic Drug Analysis

*Nominal ID at syringe needle expulsion point.

For liners for other instruments, refer to our catalog or website.

For Agilent GCs

ea.

cat.#

/price

5-pk.

25-pk.

Gooseneck Splitless, Base Deactivated (4.0mm ID* x 6.5mm OD x 78.5mm)

20798-210.1

$44

20799-210.5

$130

20800-210.25

$490

Gooseneck Splitless, Base Deactivated w/ Base Deactivated Wool (4.0mm ID* x 6.5mm OD x 78.5mm)

20798-211.1

$47

20799-211.5

$145

20800-211.25

$525

Split Straight, Base Deactivated w/ Base Deactivated Wool (4.0mm ID* x 6.3mm OD x 78.5mm)

20781-211.1

$41

20782-211.5

$129

20783-211.25

$468

Cyclosplitter

, Base Deactivated (4.0mm ID* x 6.3mm OD x 78.5mm)

20706-210.1

$59

20707-210.5

$222

20708-210.25

$772

Mini Wool Puller/Inserter

Insert and remove wool plugs easily.

Description

qty.

cat.#

price

Mini Wool Puller/Inserter

2-pk.

20114

$15

Inlet Liner Removal Tool

• Easily remove liner from injector—no more burned fingers.

• Made from high-temperature silicone.

• Won’t chip or crack the liner.

Description

qty.

cat.#

price

Inlet Liner Removal Tool

3-pk.

20181

$27

Rtx®-5 Amine Columns (fused silica)

(Crossbond

5% diphenyl/95% dimethyl polysiloxane)

df (μm)

temp. limits

length

cat. #

price

0.25mm 0.25

-60 to 300/315°C

15-Meter

12320

$335

0.25mm 0.25

-60 to 300/315°C

30-Meter

12323

$510

Reference

1. Seyhan N. and D.C. Ege,

Organic Chemistry

Health and Company,

1984, pp.124-136.

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