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Figure 3 USP Residual Solvent Class 2 Mixture B standard solution
on an Rtx®-624 (G43) column.
• 7 • 2007 vol. 2
Pharmaceutical
Restek can supply all your USP 467 materials and
can help you optimize your testing within the con-
straints of the method. Visit us on the web at
or contact our Technical Support
team at 800-356-1688, ext.4, for solutions to your
residual solvent testing needs and tips on optimiz-
ing your analysis.
0 10 20 30 40
Time (min)
8 10 12 14 16 18 20 22 24 26
Time (min)
GC_PH00911
GC_PH00911A
1. hexane
2. nitromethane
3. chloroform
4. 1,2-dimethoxyethane
5. trichloroethylene
6. pyridine
7. 2-hexanone
8. tetralin
1
2
3
4
5
6
7
2 43 5 6 7
8
For conditions see Figure 1
Sample:
USP 467 Class 2 Mixture B
Standard Solution
(cat.# 36280) in 20mL
headspace vial
did you know?
Restek offers a full day seminar
on headspace analysis. Join us
September 26, in Edison, NJ
for a day of learning focused
exclusively on headspace
principles, techniques, and
applications (cat.# 65563).
To register, visit us online at
for more info
•Technical poster:
Comprehensive Dual-Column
Analysis of Residual Solvents
in Water-soluble Articles
Using Dynamic Headspace
and Modular Accelerated
Column Heating.
• A Technical Guide for Static
Headspace Analysis Using
GC,cat.# 59895A.
•OVI retention time index
benzene 10mg/mL
carbon tetrachloride 20
1,2-dichloroethane 25
1,1-dichloroethene 40
1,1,1-trichloroethylene 50
Quantity discounts not available.
Residual Solvents - Class 1
In dimethyl sulfoxide, 1mL/ampul
cat. # 36279 (ea.) $45
acetonitrile 2.05mg/mL
chlorobenzene 1.80
cyclohexane 19.40
cis-1,2-dichloroethylene 4.70
trans-1,2-dichloroethylene 4.70
1,4-dioxane 1.90
ethylbenzene 1.84
methanol 15.00
methylcyclohexane 5.90
methylene chloride 3.00
tetrahydrofuran 3.45
toluene 4.45
m-xylene 6.51
o-xylene 0.98
p-xylene 1.52
Residual Solvents Class 2 - Mix A (15 components)
In dimethyl sulfoxide, 1mL/ampul
cat. # 36271 (ea.) $39
Siltek® 1mm Split Liners for Agilent GCs
*Nominal ID at syringe needle expulsion point.
Benefits/Uses:
ID*/OD &
Length (mm)
cat.#/price
ea.
cat.#/price
5-pk.
for purge & trap
inlet splitting or
sample <1μL
1.0 ID
6.3 OD x78.5
20972-214.1
$31
20973-214.5
$95
Rtx®-624 (G43) Columns (fused silica)
(Crossbond ® 6% cyanopropylphenyl/94% dimethyl polysiloxane)
ID df (μm) temp. limits length cat. # price
0.32mm 1.80 -20 to 240°C 30-Meter 10970 $505
0.53mm 3.00 -20 to 240°C 30-Meter 10971 $535
Stabilwax® (G16) Columns (fused silica)
(Crossbond® Carbowax® polyethylene glycol)
ID df (μm) temp. limits length cat. # price
0.32mm 0.25 40 to 250°C 30-Meter 10624 $460
0.53mm 0.25 40 to 250°C 30-Meter 10625 $525
New singles & custom
mixes for USP testing!
We can supply all your residual
solvent reference materials—For
details, see our catalog or visit us
online at
chloroform 60μg/mL
1,2-dimethoxyethane 100
n-hexane (C6) 290
2-hexanone 50
nitromethane 50
pyridine 200
tetralin 100
trichloroethylene 80
Quantity discounts not available.
Residual Solvents Class 2 - Mix B (8 components)
In dimethyl sulfoxide, 1mL/ampul
cat. # 36280 (ea.) $35
Use this liner for increased sensitivity. Exclusive Siltek®
deactivation makes liner inert to active sample components.