ADV06-15_1-412

28 / 413

| 1-800-356-1688 or 1-814-353-1300 | Feedback? E-mail 2
One night, I stopped by the Restek
Innovations Laboratory to grab something
from my office and stood for a moment
in the dark. Looking out over the sea of
LED lights and listening to the whine of
pumps and cooling fans that is so familiar
to GC and LC chemists around the world,
I was reminded of my time working in an
environmental lab. When the work was done and the instruments were up and running, I
would shut off the lights and reflect for a moment on the day. But, my trip down memory
lane was interrupted by the sound of an autosampler moving a vial into position—most
likely Chris Rattray’s instrument running a calibration curve for 1,4-dioxane by LVSI (page
6) or a semivolatile analysis with an extended calibration range (page 8). After all, with the
aid of autosamplers, the lab never sleeps. Case in point, this Advantage is packed full of
data generated at all hours of the day and night.
Our latest issue brings you a wide breadth of applications, like the ones mentioned above,
produced by dedicated, passionate chemists like yourself. Julie Kowalski, Sharon Lupo
and Amanda Rigdon use LC-MS/MS techniques for work ranging from pesticide analysis
to therapeutic drug monitoring. Rick Lake and Ty Kahler help you find the best LC-MS col-
umn, then use it to analyze sulfonamides. If you use a GC, Scott Grossman will shatter your
perceptions of injection ports. We also explore matrix effects in complex samples both
with a guest editorial and with Jack Cochran’s and Julie Kowalski’s discussion of pesticide
recoveries using LC-MS/MS and GCxGC-TOFMS.
There’s something for everyone in this Advantage. We hope it helps you reach that place
where you can turn the lights off and enjoy the ambience of the laboratory.
Cheers!
Chris English
Laboratory Manager,
Innovations Group
In This Issue
Connections. . . . . . . . . . . 2–3
Hot Topics. . . . . . . . . . . . 4–5
Technical Articles. . . . . . . . 6–23
Lowering Detection Limits for 1,4-Dioxane
in Drinking Water Using LVSI in an
Unmodified Splitless GC Inlet . . . . . . . 6–7
Quantify Semivolatiles Down to 0.5 ng
with an Extended Calibration Range . . . 8–9
It’s A Matter of Degrees, but Do Degrees
Really Matter? An Observation of GC Inlet
Temperature Profile and Variability. . . . 10–11
Comprehensive Pesticide Residue
Monitoring in Foods Using QuEChERS,
LC-MS/MS, and GCxGC-TOFMS. . . . . 12–13
Increase Data Quality for Sulfonamides by
HPLC and UHPLC Using Unique Biphenyl
Column Selectivity. . . . . . . . . . . 14–15
Fast, Robust LC-MS/MS Method for
Multiple Therapeutic Drug Classes. . . . 16–17
Find the Best LC-MS Column/Mobile Phase
Combination Using USLC® Columns and a
Scouting Gradient. . . . . . . . . . . . . 18–19
Improve Trace Analysis of Polar Impurities
in Petroleum Gases Using Higher Sample
Capacity Alumina MAPD Columns . . . 20–21
Editorial: Matrix Effects in Multi-Residue Pesticide
Analysis When Using Liquid Chromatography-
TandemMass Spectrometry. . . . . . . . 22–23
About Restek Corporation
A leading innovator of chromatography solutions
for both LC and GC, Restek has been developing
and manufacturing columns, reference standards,
sample preparation materials, accessories, and
more since 1985. We provide analysts around the
world with products and services to monitor the
quality of air, water, soil, food, pharmaceuticals,
chemicals, and petroleum products. Our experts
enjoy diverse areas of specialization in chemistry,
chromatography, engineering, and related fields
as well as close relationships with government
agencies, international regulators, academia, and
instrument manufacturers.
Patents and Trademarks
Restek patents and trademarks are the property
of Restek Corporation. Other trademarks appear-
ing in Restek literature or on its website are the
property of their respective owners. The Restek
registered trademarks used here are registered in
the United States and may also be registered in
other countries.
Reflections from the Bench
Restek Connections
You Have Opinions... And We Want Them
We chemists are an opinionated bunch, so the odds are good that you have
some thoughts about the Restek Advantage. Love it? Hate it? Want to see
something different in the next issue? Maybe you have a response to one of our
technical articles? Whatever you have to say, let’s hear it! Email your comments to
and you may even see them in an upcoming issue.