Development of the
Rtx-OPPesticides2
Column
In the development of theRtx-OPPesticides2 column, datawas first
acquired for target compounds under two temperature programs.
Columnswith functionalities that displayed selectivity for these
compoundswere used.
ComputerAssistedStationaryPhaseDesign
(CASPD)was used to calculate
∆
Hand
∆
S for each compound.
By
working inRetention Index, the phase anddimensions couldbe
optimized for the target separation.
The stationaryphase can thenbe
synthesized and the column coated at the appropriate phase thickness.
Belowis a simple 3-Dmodel depicting a polymer composition for 3
compounds.
This is a simplifiedmodel describing the 53 compounds
whichweremodeled for theRtx-OPPesticides2 column.
