StationaryPhaseOptimization
Stationaryphase optimization canbe achieved throughwindow
diagrammingor bycomputer simulationof the retention time, R
t
, and
peakwidth at half height,
W
1/2
.
Simulationprograms such as ezGC
have been applied in the development of phases such as theRtx®-
CLPesticides and Rtx-CLPesticides2.
The next step inpolymer development involves the computer
predictionof optimized stationaryphase composition and column
dimensions.
This approachuses computer predictionof
solute/stationaryphase interactions to aid in the designof new
polymers.
Columns such as theRtx-TNT, Rtx-TNT2, Rtx-VMS,
Rtx-VGC, Rtx-5SilMS, Rtx-VRX, andRtx-OPPesticides2were
developedusing this approach.
