206 / 582
Simulated Distillation
• The chromatogram of the sample is divided into time slices
• The software determines the area count for each slice
1
2
3
4
5
6
7
8
9
10
Response
A
1
A A
3
A
4
A
5
A
6
A
7
A
8
A
9
A
10
Retention time
Challenges
• Columns Break (fused silica)
• Columns loose stationary phase by bleed
– Need to recalibrate often (time)
– Replace columns (price per analysis, time)
– Reduced accuracy (reliability challenge)
• Columns are not efficient
– Do not meet resolution requirements
Needs for Accurate Simulated
Distillation Analysis
• High temperature stable columns
• Low Bleed phases