695
GC CHROMATOGRAMS |
PHARMACEUTICAL
Organic Volat i le Impur i t ies/Residual Solvents
Column:
Rxi
®
-624Sil MS, 30 m, 0.32mm ID, 1.80 µm (cat.# 13870)
Sample:
Residual Solvents Class 2 - Mix B (cat.# 36280)
Diluent:
water
Injection:
headspace-loop split (split ratio 5:1)
Liner:
1 mm Split (cat.# 20972)
Headspace-Loop
Inj. Port Temp.:
140 °C
Instrument:
Tekmar HT3
Inj. Time:
1 min.
Transfer Line Temp.:
110 °C
Valve Oven Temp.:
110 °C
Sample Temp.:
80 °C
Sample Equil. Time:
60 min.
Vial Pressure:
10 psi
Pressurize Time:
0.5 min.
Pressure Equilibration Time: 0.05 min.
Loop Pressure:
5 psi
Loop Fill Time:
0.1 min.
Oven
Oven Temp:
40 °C (hold 20 min.) to 240 °C at 10 °C/min. (hold 20 min.)
Carrier Gas:
He, constant flow
Linear Velocity:
35 cm/sec.
Dead Time:
1.45 min. @ 40 °C
Detector:
FID @ 250 °C
Data Rate:
5 Hz
Instrument:
Agilent/HP6890 GC
Acknowledgement:
Teledyne Tekmar
Peaks
RT (min.) Conc. (µg/mL)
1. Hexane
5.355
2.42
2. Nitromethane
6.793
0.42
3. Chloroform
8.092
0.50
4. 1,2-Dimethoxyethane
9.980
0.83
5. Trichloroethene
12.941
0.67
6. Pyridine
21.303
1.67
7. 2-Hexanone
24.862
0.42
8. Tetralin
33.781
0.83
GC_PH1148
Class 2—Mix B Residual Solvents for Water-Soluble Articles on Rxi®-624Sil MS
NEW!
free
literature
Residual Solvent Analysis
Implementing USP <467>
Download your copy from
Applications Note
lit. cat.# PHFL1018A
Website :
E-mail :
TelNo : 03 9762 2034 . . . in AUSTRALIA
Mar 2011
