In drug development, time-to-market is everything, but finding the right column can be laborious and
time-consuming.Commonly,“624”(6% cyanopropyl phenyl/94%dimethyl polysiloxane) type columns
areused forGC/FID impurity analyses toprovide thenecessary selectivity, butwhenmass spectrometry
is needed,methoddevelopment often startswith lower bleed“1”(100%dimethyl polysiloxane) and“5"
(5% diphenyl/95% dimethyl polysiloxane) type columns. Now, you can get tomarket faster andmore
efficiently by using a single column that combines these attributes—the new Rxi®-624Sil MS column.
Withenhanced retentionand selectivityof polarcompounds,compatibilitywithmass specdetectors,and
unsurpassed inertness,Rxi®-624SilMScolumns are themostbroadlyapplicableGCcolumns available to
the pharmaceutical industry. Speed up successful method development by making Rxi®-624Sil MS
columns your“go to”columnof choice for polar impurities.
GoTo…
the right column first
For better retentionof polar analytes and improved accuracy, peak shape,
and response for active compounds.
GoTo…
mass specdirectly
With the lowest bleed 624 column available; stable up to 320 °C, for easy transfer of methods toGC/MS.
GoTo…
thenext batch faster
With the best-in-classG43 forUSPmethods.
AccelerateDevelopment
Howdidwe create the
Rxi
ColumnFamily?
We’ve optimizedphase chemistry, columndeactivation, andourmanufacturing process to ensure
the comprehensive performance thatmakes Rxi®-624SilMS columns the best starting point for
methoddevelopment.
RxiDeactivation
• Effectively shields reactive silanols
• Ensures comprehensive inertness
(acids andbases)
• Provides symmetric peaks
Polyimide
FusedSilica
RxiManufacturing
Tighter quality controls for better
performance and column-to-column
reproducibility
Rxi PhaseChemistry
• Enhances selectivity
• Increases thermal stability
• Lowers bleed forMS compatibility
• Surface bonding increases durability
Rxi®-624SilMS
The
GoTo
GCColumn forFast, EffectiveVolatile
ImpuritiesMethodDevelopment
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Website :
E-mail :
TelNo : 03 9762 2034 . . . inAUSTRALIA
