Figure3
Primaryamines, suchas isopropylamine, canbemoreaccurately integratedonanRxi®-624SilMScolumn,
lowering levelsofquantification (LOQs) and increasingmethodaccuracy.
Inaddition toofferingbetter retentionof polaranalytes,Rxi®-624SilMScolumnsareexceptionally inert, reducing theneed to switch
columnswhendevelopingmethods for active compounds, such as amines.Amines are commonly foundonpharmaceutical impu-
rities and can interact with surface silanols resulting in a tailing peak. Proper deactivation is the best way to combat this, andRxi®
technologyprovides themost balanceddeactivation, assuring goodpeak symmetry for bothbasic and acidic compounds.Columns
that are not effectively deactivated for basic compounds produce unacceptable peak tailing (Figure 2). In contrast, the Rxi®-624Sil
MS columnprovides excellent peak shape,which leads to consistent peak integration, improved linearity, andhighermethod sensi-
tivity (Figure 3).
Figure2
InnovativeRxi®deactivation technologyprovidesexcellentpeak symmetryat 5ngon-column forprimary,
secondary, and tertiaryamines,which isnotpossibleoncompetitivecolumns.
Column
30m, 0.32mm ID, 1.8µm (cat.# 13870)
Sample
Isopropylamine
Diluent:
DMSO
Conc.:
100µg/mL
Injection
Inj. Vol.:
1µL split (split ratio 20:1)
Liner:
5mm SingleGooseneckwithWool (cat.# 22973-200.1)
Inj.Temp.:
250 °C
Oven
OvenTemp:
50 °C (hold 1min.) to 200 °C at 20 °C/min. (hold 5min.)
Carrier Gas
He, constant flow
Linear Velocity: 37 cm/sec.
Detector
FID@ 250 °C
Instrument
Agilent/HP6890GC
GC_PH1162
Peaks
Conc.
(µg/mL)
1. Isopropylamine
100
2. Diethylamine
100
3. Triethylamine
100
Highly inertRxi®-624SilMScolumns
giveexcellentpeaksymmetry.
GoTo...
theRightColumnFirst
Balanced InertnessGivesHigherDataQuality—
ExcellentPeakSymmetryandReproducibility forActiveCompounds
GC_PH1164
GC_PH1163
ZB-624
Integrationnot possible
below25ng
Rxi®-624SilMS
5-100ngon-column,
R
2
=0.99996
Exceptionalpeaksymmetry
and retention timestability
result inhighsensitivityand
linearityon theRxi-624SilMS
Same conditions as figure2.
Rxi
®
-624Sil MS
DB-624
ZB-624
4
Website :
E-mail :
TelNo : 03 9762 2034 . . . inAUSTRALIA
