Figure4
Rxi®-624SilMScolumnsprovide thebestoverall inertnessand selectivity for
ethyleneglycol anddiethyleneglycol impurities inglycerin, glycol, or sorbitol solutions.
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LC/MS/MS does not automati-
cally qualify one to runGC/MS.
JulieKowalski spent timewith
me tohelpme decidewhich
columnwouldbe the best for
my application aswell aswhich
consumables Iwouldneed to
do routinemaintenance. The
time and knowledge she shared
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Other active compounds, such as glycols, also exhibit peak tailing as a result of reactivitywith the chro-
matographic system. For example, when analyzing ethylene glycol and diethylene glycol in glycerin
according toanewFDAGuidance for Industry,only theRxi®-624SilMS columngives the selectivityand
peak symmetryneeded for these reactivecompounds (Figure4).Satisfy thisandother industryguidances
quickly, by choosing the right column, the first time.
Column
30m, 0.32mm ID, 1.80µm (cat.# 13870)
Sample
Diluent:
methanol
Injection
Inj. Vol.:
1µL split (split ratio 10:1)
Liner:
5mm SingleGooseneckwithWool (cat.# 22973-200.1)
Inj.Temp.:
220 °C
Oven
OvenTemp:
100 °C (hold 4min.) to 120 °C at 50 °C/min. (hold 10min.)
to 220 °C at 50 °C/min. (hold 6min.)
Carrier Gas
He, constant flow
Linear Velocity: 40 cm/sec.
Detector
FID@ 250 °C
Instrument
Agilent/HP6890GC
Notes
Columns tested: Rxi
®
-624Sil MS, ZB-624, andDB-624
GC_PH1151
Peaks
RT (min.)
Conc.
(mg/mL)
Ethylene glycol
3.757
0.05
Propylene glycol
4.422
2.0
2,2,2-Trichloroethanol (IS)
7.461
0.1
Diethylene glycol
10.416
0.05
Couple the right column
with the right liner.Visit
for acomplete
selection.
GoTo...
theRightColumnFirst
Rxi
®
-624Sil MS ZB-624 DB-624
USP tailing
(ethylene glycol)
1.8
2.7
1.8
Resolution
(ethylene glycol/
propylene glycol)
9.7
8.4
7.2
Best inClass—Rxi®-624SilMS
Rxi®-624SilMS
ZB-624Column
DB-624Column
5
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E-mail :
TelNo : 03 9762 2034 . . . inAUSTRALIA
