739
HPLCCHROMATOGRAMS |
PHARMACEUTICAL
Antiarrhythmics, Antiasthmatics
AntiarrhythmicCalciumChannelBlockers
onUltraCyano
1
Peak List:
1. diltiazem
2. nifedipine impurity
3. verapamil
4. nifedipine
5. nicardipine
LC_0062
0
1
2
3
4
5
6
7
8
9 min.
2
3
4
5
Sample:
Inj.:
5µL
Conc.:
100mg/mL
Solvent:
acetonitrile:water (1:1)
Column:
Ultra Cyano
Cat.#:
9106565
Dimensions:
150mm x 4.6mm
Particle size:
5µm
Pore size:
100Å
Conditions:
Mobile phase:
20mM potassium
phosphatemonobasic,
pH3.0:acetonitrile (70:30, v/v)
Flow rate:
1.2mL/min.
Temp.:
30°C (±1°C)
Det.:
235nm
AntiarrhythmicFurosemideonUltra IBD
Peak List:
1. uracil (marker)
2. furosemide
Sample:
Inj.:
5µL
Conc.:
1000µg/mL
Solvent:
acetonitrile:water
(60:40, v/v)
Column:
Ultra IBD
Cat.#:
9175565
Dimensions:
150mm x 4.6mm
Particle size:
5µm
Pore size:
100Å
Conditions:
Mobile phase:
20mM ammonium
acetate, pH 4.5:
acetonitrile
(70:30, v/v)
Flow rate:
2.0mL/min.
Temp.:
27°C
Det.:
UV@ 280nm
LC_0071
Impurities inFurosemide
(enlargement of baseline)
Peak List:
1. beclomethasone
2. deschlorobeclomethasone
Sample:
Inj.:
10µL
Conc.:
79.5µg/mL (beclomethasone)
Solvent:
water:acetonitrile (10:90, v/v)
Column:
Ultra C18
Cat.#:
9174565
Dimensions:
150mm x 4.6mm
Particle size:
5µm
Pore size:
100Å
Conditions:
Mobile phase:
water:acetonitrile (70:30, v/v)
Flow:
1.0mL/min.
Temp.:
25°C
Det.:
UV@ 238nm
AntiasthmaticBeclomethasoneonUltraC18
0
5
10
15
20 min.
1
2
LC_0120
Chromatogram
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Mar 2011
