698
GCCHROMATOGRAMS |
PHARMACEUTICAL
Organic Volatile Impurities/Residual Solvents
GC_PH00953
1. hexane
2. 1,2-dimethoxyethane
3. trichloroethylene
4. chloroform
5. 2-hexanone
6. nitromethane
7. pyridine
8. tetralin
ResidualSolventsClass2MixB
Stabilwax® (G16)
Column:
Stabilwax
®
, 30m, 0.32mm ID, 0.25µm
(cat.# 10624)
Sample:
USP Stock Standard Residual Solvents
Class 2Mix B (cat.# 36272) in 20mL headspace
vial (cat.# 24685), water diluent
Inj.:
headspace injection (split ratio 1:5), 2mm
splitless liner IP deactivated (cat.# 20712)
Inj. temp.:
140°C
Carrier gas:
helium, constant flow
Flow rate:
2.15mL/min., 35.2cm/sec.
Oven temp.:
50°C for 20min. to 165°C@ 6°C/min.
(hold for 20min.)
Det.:
FID@ 250°C
Headspace Conditions
Instrument:
Overbrook Scientific HT200H
Syringe temp.:
100°C
Sample temp.:
80°C
Sample equil. time.: 45min.
Injection vol.:
1.0mL
Injection speed:
setting 8
Injection dwell:
5 sec.
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