693
GCCHROMATOGRAMS |
PHARMACEUTICAL
Organic Volatile Impurities: Retention Time Index
Compound
MS ion
char.ion
45(5)7/220(5)
formaldehyde
29
30,31
1.16
methanol
31
29,30,33
1.36
pentane
43
41,42,72,57,29
1.74
ethanol
31
45,46,27
1.76
diethylether
59
74,45
1.87
2-chloropropane
43
73,63,80,27
1.95
acetone
43
58,27,39
2.06
methylal
45
75,29,31
2.07
1,1-dichloroethene
61
96,61,63
2.08
2-propanol
45
43,27,59
2.15
ethyl formate
45
31,29,27,74
2.2
methyl acetate
43
74,59,29
2.33
acetonitrile
41
40,39,38
2.33
2-methylpentane
43
42,41,71,86
2.48
methylene chloride
84
49,86,51,88
2.5
methyl
tert
-buyl ether
73
57,41,43,45
2.7
trans
-1,2-dichloroethene
61
96,98,63
2.76
hexane
57
41,86,43
3.05
isopropyl ether
45
43,87,69
3.22
1-propanol
31
42,59,27
3.22
methyl cyclopentane
56
41,69,84
3.76
nitromethane
61
46,30
3.83
2-butanone (MEK)
72
43,57 (use 43)
3.9
cis
-1,2-dichloroethene
96
96,61,98
3.96
ethyl acetate
43
61,70
4
2-butanol
45
59,31
4.21
tetrahydrofuran
42
72,71,41 (use 72)
4.34
chloroform
83
83,85,47,87,118
4.51
1,1,1-trichloroethane
97
97,99,61
4.76
2,2-dimethoxypropane
73
89,43,42,31
4.81
cyclohexane
56
84,41,27
4.88
carbon tetrachloride
117
117,119
5.04
isobutyl alcohol
42
43,31,41,33
5.31
2-methoxyethanol
45
47,76
5.31
1,2-dimethoxyethane
45
60,58,90
5.41
benzene
78
78
5.41
Compound
MS ion
char.ion
45(5)7/220(5)
1,2-dichloroethane
62
62,98
5.55
isopropyl acetate
43
61,87
5.59
isooctane
57
56,41
5.63
methyl isopropyl ketone
43
41,86
6
n
-heptane (C7)
43
57,71,100
6.06
1-butanol
56
41,43,55
6.67
trichloroethene
95
95,97,134,132
6.73
methyl cyclohexane
83
55,98
7.17
1,4-dioxane
88
58,43,57
7.43
propyl acetate
43
61,73
7.61
2-ethoxyethanol
59
31,45,72
8.12
pyridine
79
52,50,51
9.04
hexanone (MIBK)
43
58,56,85,100
9.17
isoamyl alcohol
55
42,41,43,70
9.33
toluene
91
92,65,51
9.37
ethylene glycol
31
33
9.69
isobutyl acetate
43
56,73
9.91
1-pentanol
42
55,70,41
10.43
formamide
45
29,44
10.49
1,1-diethoxypropane
59
47,87,103
10.79
2-hexanone (MBK)
43
58,57,100
10.88
butyl acetate
43
56
11.31
dimethyl formamide (DMF)
73
44,58
11.68
chlorobenzene
112
112,77,114
12.35
ethylbenzene
91
91,106
12.64
p
-xylene
106
106,91
12.93
m
-xylene
106
106,91
12.93
isoamyl acetate
43
55,70
13.28
o
-xylene
106
106,91
13.74
dimethyl sulfoxide
78
63,45
14.06
N,N-dimethylacetamide
87
44,43,72
14.45
isopropylbenzene (cumene)
105
120,77
14.55
anisole
108
78,65,51
14.72
1-methyl-2-pyrrolidinone
99
98,44,42
19.54
1,2,3,4-tetrahydronaphthalene
104
132,117,91,65
21.39
sulfolane
41
56,55,120
24.77
Rxi®-624SilMS
20m x 0.18mm x 1.0µm df
DeadTime 0.81minutes Constant Flow
Initial 45°C (hold 5min.) 7C/min. to 220°C (hold 5min.)
Reducemethoddevelopment time—usea retention time index for column selection.
for
more
info
See
pages 694-695 for Rxi
®
-624Sil MS chromatograms.
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