Solution (aka future state): NeSSI,microGC
andChemometricswithFullAutomation
AutomationStrategy
Use smart software
Evaluate step by step results as a
humanwould
On alarm, stop and notify a human
On success proceed to the next step
AutomationSuite of Elements
IntraFlow
tm
NeSSI
Switches streams
Monitors critical parameters: T, P, F
Calidus&ChromPerfect (CP)
Performs chromatographicanalyses
CP operatingCalidus, NeSSI &directing
data flow is themaster
Receivespermissions from& reports
(alarms) results toSCADA
LineUp& InStep
Aligns chromatograms to target
chromatogram
Assesses results as “consistent with
expectations” or “outlier, sound thealarm”
1)
ChromPerfectwatches for stream ID andpermission from the SCADA system
i)
Stream ID is defined as FreezeDrier E, ForG
ii)
Permission indicates the sequence of operation for that freeze driermaybegin
iii) ChromPerfect starts the appropriate streamvacuumpump
2)
On permission, ChromPerfect downloads the appropriatemethod and sequence to
Calidus
i)
Methods include operating conditions anddata processingparameters
ii)
Sequences include sample identification andnumber of runs as follows
(1)
Run5 blanks (analytical cyclewithout actuating the sample valve)
Assess results as clean (pass, continue) or dirty (fail, stop and alarm)
(2)
Run1 zero air
Assess results as system suitable (pass, continue) or not suitable (fail, stop
and alarm)
(3)
Run1 validation sample
Assess results as system suitable (pass,
continue) or not suitable (fail, stop and
alarm)
(4)
Run5 freeze drier samples and report
(a)
Each chromatogram to be displayed
(b)
Sample data, P, T and other assessment
parameters
(c)
Component name
(d)
Retention time (if Syltherm)
(e)
Total area
(f)
CalculatedConcentration
(g) Assess results as validmeasurement (pass, continue or not valid (fail,
stop and alarm)
3)
Report results
i)
Average last three of the 5 runs
ii)
Report average concentration
Assessment of the FreezeDryer condition (cleanor alarm)
