CLINICAL/FORENSICS
1
Introduction
Introduction
In the clinical and forensicmarkets, chromatography encompasses
awide range of application areas, including:
• hospital& forensic toxicology
• drugs of abuse
• alcohol&driving
• workplace drug testing (illicit drugs)
• drug abuse in sports (steroids, stimulants, analgesics, hormones,
diuretics, narcotics)
• therapeutic drugmonitoring (prescriptiondrugs)
• natural toxins (hallucinogenicmushrooms)
• pesticide poisoning
• volatile substance abuse (adhesives, dry cleaning/degreasing agents,
hydrocarbon fuels, solvents, paint strippers/thinners, vasodilators)
• soliddrug identification
Example chromatograms for a variety of these applications, obtainedusing
RestekGC andHPLC columns and accessories, are illustrated in this guide.
Throughout thisguideyoualsowill find references toapplicationnotes that
detail specific analyses, technical guides that explainvarious analytical tech-
niques, product information pieces that highlight aspects of our products,
and reference books that offer detailed information on topics from sample
preparation to chromatographicmethods.All Restekpublications are avail-
able freeon request; orderby contactingourTechnical ServiceDepartment,
our Customer Service Department, or your Restek distributor by e-mail,
telephone, or fax, andproviding the literature catalognumbers for thepub-
lications you want. For fastest access, you can review and download these
publications from our website. For prices for reference books, refer to our
general catalog or website - or simply call our Customer Service
Department.
TableofContents:
Introduction
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Applications
ArsonAccelerants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2,3
Abused Inhalants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
Anesthetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
Butyrolactone, Butanediols . . . . . . . . . . . . . . . . . . . . . . 5
Barbiturates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6,7
Benzodiazepines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
BasicDrugs (Mixed) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8,9
BloodAlcohol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10,11
Solvents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Cannabinoids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
Opiates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
Cocaine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
Phencyclidine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
Glycols . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
Phenothiazines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
SympathomimeticAmines . . . . . . . . . . . . . . . . . . 15-17
AnalgesicFormulations . . . . . . . . . . . . . . . . . . . . . . 18,19
Antidepressants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20,21
Antihistamines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Antiepileptics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22
CardiacMedications . . . . . . . . . . . . . . . . . . . . . . . . . 23,24
CNSDepressants (Sedatives) . . . . . . . . . . . . . . . . . . . . 24
Cold&SinusMedications . . . . . . . . . . . . . . . . . . . . . . . 25
Steroids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26,27
ChiralDrugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28
ProductListings
GCColumns . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29-38
GCAccessories . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39-46
HPLCColumnsandGuardColumns . . . . . . . . . 47-52
HPLCAccessories . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53-57
VialsandSyringes . . . . . . . . . . . . . . . . . . . . . . . . . . . 58,59
SamplePreparation . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60
Analytical ReferenceMaterials . . . . . . . . . . . . . . . 61-64
Kristi Sellers
Clinical/Forensic
InnovationsChemist
three
simple
words...
Plus 1
Exceeding your expectations
in everythingwe do.
Innovation
Turning visions into reality
™
.
Execution
On-time delivery of products and services.
Restek’s vision is to be the company that chromatographers trust by providing the highest quality,
most innovative products and services throughout theworld.
Wewill soon reach our goal of 100% employee ownership.
As owners, our success depends on your success.
Restek Trademarks:
Allure, Alumaseal, CarboBlack, Crossbond, Cyclosplitter, FAME-
WAX, FastPack, IceBlue, InfraRed, Integra-Guard, MXT, Pinnacle,
Precision, Rt-ßDEXcst, Rt-ßDEXm, Rt-ßDEXsa, Rt-ßDEXse, Rt-
ßDEXsm, Rt-ßDEXsp, Rt-CW20M, Rt-
γ
DEXsa, Rtx, Silcoport,
SilcoSleeve, SilcoSmooth, Silcosteel, Silcote, Siltek, Stabilwax,
Thermolite,Trident,TurningVisions IntoReality, Uniliner, XTI
Other Trademarks:
Agilent HP (AgilentTechnologies, Inc.), Mylar,Teflon,Tefzel,
Vespel, Viton (E.I. duPont deNemours&Co., Inc.), Ultra
(Hewlett-PackardCorp.), Hypersil (Hypersil, Life Sciences Intl.
Co.), DB (J&W Scientific), Chromosorb (ManvilleCorp.), Bentone
(National LeadCo. Baroid SalesDiv.), OV (OhioValley Specialty
Chemical Co.), Parker A-Lok (Parker InstrumentationDivision),
NUKOL, PTE, SP, SPB, SUPELCOWAX, VOCOL (Sigma-AldrichCo.),
Carbowax (UnionCarbideCorp.), Upchurch (Upchurch Scientific),
Valco (Valco Instruments Co, Inc.), PEEK (Victrex plc), Clean-Cut,
Opti-Cap (Jour Research),TRACE (Thermo ElectronCorp.), LO-
Pulse (Scientific Systems, Inc.), Swagelok (Swagelok Company),
Rheodyne (Rheodyne LP),Waters (Waters Associates, Inc.)
List is accurate to the best of our knowledge at the time of print-
ing. Consult individual manufacturers or other sources for spe-
cific information.
Kristi brings 18 years of experience inGC and 4 years of
experience inHPLC to her role as our principal clinical and
forensic applications chemist. She holds a B.S. in chemistry
from Lock HavenUniversity, Lock Haven, PA.
E-mail:
Phone: 800-356-1688 or 814-353-1300, ext. 2150
