Rtx015-16-628

99 / 629

97
GC COLUMNS | APPLICATION-SPECIFIC COLUMNS
Pharmaceutical
Rtx®-G27 Column (fused silica with 5-meter Integra-Guard® guard column)
(Crossbond® diphenyl dimethyl polysiloxane)
• Application-specific columns for residual solvents in pharmaceutical products.
• Analytical column with Integra-Guard® guard column eliminates connecting
problems and leaks.
• Rtx®-G27 stable to 290 °C.
Some methods require the use of a guard column. Our Integra-Guard® integrated
guard column system makes it easy to comply.
Rtx®-G43 Column (fused silica with 5-meter Integra-Guard® guard column)
(Crossbond® cyanopropylmethyl phenylmethyl polysiloxane)
• Application-specific columns for residual solvents in pharmaceutical products.
Meet all requirements of USP <467>.
• Analytical column with Integra-Guard® guard column eliminates connecting
problems and leaks.
• Rtx®-G43 stable to 240 °C.
Some USP <467> methods require the use of a guard column. Our Integra-Guard®
integrated guard column system makes it easy to comply.
Organic Volatile Impurities (OVI) Analysis
Download y
A Technical Guide for
Static Head
Analysis
Using GC
lit. cat.#
59895B
free literature
Custom Re
Solvents
Mixes
lit. cat.#
PHTS1212
30-Meter with 5-Meter, 0.53mm ID Integra-Guard Guard Column
ID df temp. limits cat.# price
0.53 mm 5.00 µm -60 to 270/290 °C 10279-126
30-Meter with 5-Meter, 0.53mm ID Integra-Guard Guard Column
ID df temp. limits cat.# price
0.53 mm 3.00 µm -20 to 240 °C 16085-126
0 10 20
1
2
3
4
5
Time (min)
USP <467> Residual Solvents on Rtx®-1301 (G43) by Static Headspace
GC_PH00810
Column Rtx®-1301 w/5 m Integra-Guard®, 30 m, 0.53 mm ID, 3.00 µm
(cat.# 16085-126)
Sample USP <467> calibration mixture #5 (cat.# 36007)
Diluent: DMSO
Conc.: To each 22 mL headspace vial 5ml water, ~ 1.0 g of sodium
sulfate and 100 µL of stock standard were added.
Injection headspace-loop split (split ratio 2:1)
Headspace-Loop
Inj. Port Temp.: 180 °C
Instrument: Teledyne Tekmar HT3
Inj. Time: 1.0 min
Transfer Line Temp.: 150 °C
Valve Oven Temp.: 150 °C
Standby flow rate: 10 mL/min
Sample Temp.: 80 °C
Platen temp equil. time: 2.0 min
Sample Equil. Time: 15.0 min
Mixer time: 2.0 min
Mixing level: 5
Mixer stabilize time: 0.5 min
Vial Pressure: 15 psi
Pressurize Time: 2.0 min
Pressure Equilibration Time: 0.5 min
Loop Pressure: 5 psi
Loop Fill Time: 2.0 min
Loop fill equil. time: 0.5 min
Oven
Oven Temp.: 40 °C (hold 20 min) to 240 °C at 25 °C/min (hold 10 min)
Carrier Gas He, constant flow
Flow Rate: 5 mL/min
Detector FID@ 250 °C
Make-up Gas Flow Rate: 45 mL/min
Notes FID conditions:
hydrogen flow: 40 mL/min
air flow: 450 mL/min
Peaks tR (min) Conc. (µg/mL)
1. Dichloromethane 5.110 12.0
2. Chloroform 9.285 1.2
3. Benzene 11.173 0.04
4. Trichloroethylene 14.647 1.6
5. 1,4-Dioxane 17.436 7.6