Basic HTML Version
0.0
0.5
1.0
1.5
2.0
2.5
3.0
3.5
min
-25
0
25
50
75
100
125
150
mAU
268nm4nm (1.00)
1
4
5
3
2
Mobile Phase:
A
: 20 mM potassium
phosphate (pH 2.5 w/ H
3
PO
4
)
B: Methanol
Time:
%B
0min
5%
4min
35%
Flow: 1.2 mL/min
Temp.: 40°C
Det.: UV @ 268 nm
Impurity Analysis of Antacid Tablets
Famotidine and Recognized Impurities
Ultra II Aromax 2.2µm, 50 x 3.0mm
1 – Impurity A
2 – Impurity B
3 – Impurity C
4 – Famotidine
5 – Impurity D
36
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