Basic HTML Version
0.0
1.0
2.0
3.0
4.0
5.0
6.0
7.0
min
-25
0
25
50
75
100
125
150
175
200
225
mAU
268nm4nm (1.00)
1
4
5
3
2
Mobile Phase:
A
: 20 mM potassium
phosphate (pH 2.5 w/ H
3
PO
4
)
B: Methanol
Time:
%B
0 min
5%
8 min
35%
Flow: 1.2 mL/min
Temp.: 40°C
Det.: UV @ 268 nm
Impurity Analysis of Antacid Tablets
Famotidine and Recognized Impurities
Ultra II Aromax 3µm, 150 x 3.2mm
1 – Impurity A
2 – Impurity B
3 – Impurity C
4 – Famotidine
5 – Impurity D
35
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