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Impurity Analysis of Antacid Tablets
Famotidine and Recognized Impurities
Ultra II Aromax 5µm, 150 x 3.2mm
1 – Impurity A
2 – Impurity B
3 – Impurity C
4 – Famotidine
5 – Impurity D
Mobile Phase:
A
: 20mM potassium
phosphate (pH 2.5 w/ H
3
PO
4
)
B: Methanol
Time:
%B
0min
5%
15min
35%
Flow: 2.0 mL/min
Temp.: 40°C
Det.: UV @ 268 nm
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