Analysis of CommonSolventsUsing
TwoColumns
The following conditions apply to both chromatograms
shown (Rtx-G27&Rtx-VGC), theonly deviation from
these parameters is the film thickness of theRtx-VGC,
which is 3.0microns. The chromatograms are
Headspace injections of 24 common residual solvents
for pharmaceutical processing. Prepared to equal
about 500ppm in the bulk pharmaceutical. TheRtx-
VGCwouldmake a suitable confirmation column to the
G27 phase for this compound set, but a column
specifically engineered for these compounds could be
used for a variety of methods and provide better
resolution.
