Challenges in InterfacingLC toMS
FlowRateConcerns
Differential pumping can only handle 2
µ
L/min of water
Formaximum sensitivity, want to use all of
the eluent
Useof Buffers andAdditives
Non-volatile buffers a concern
Some additives suppress ionization
WideRangeof Analytes
Many arenonvolatile, thermally labile
