AtmosphericPressure Interfaces (API)
–Early 1990’s (commercialization)
–Nowmost common interface
–Electrospray (ESI)
¾
Initial interfaces required lower flows (1-5uL/min)
¾
Able to producemultiply-chargedmolecules
–AtmosphericPressureChemical Ionization
¾
Similar toThermospray
¾
“Solvent-mediated” ionization
Historical Perspective
