Historical Perspective
• First LC-MS interfacedeveloped - 1969
–1uL/min flow into anEI source
• Transport devices applied toLC/MS - 1970’s
–Loss of volatile components
–Thermally-reactive compound losses
• Thermospray (TSI) gains popularity - 1983
–1.0 –1.5mL/min
–Mobile phases consist primarily of an
aqueous buffer
