CarboxylicAcids
Small carboxylic acids canbe difficult to retain
by reversed phaseHPLC, often requiring a highly
aqueousmobile phase. Highly aqueousmobile
phases are problematic formanyC18 columns,
leading to retention loss that is attributed to chain
folding. TheAqueousC18 columnwas designed
to enhance retentionof polar compounds and to
provide stable retention, evenwith completely
aqueousmobile phases.
