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Practical Challenges with smaller bore
columns..
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Not for on-column, direct and valve
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Has to be coupled, which is difficult and critical
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Not ideal for trace analysis
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Column flow is low: need long splitless times/small injection volumes and small volume
liners required: pressure Pulse;
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Loadability is limited
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For traces no problem; Higher level components will require thicker films
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High inlet pressures required
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Have to watch for leaks: leakage of septum and needles
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Smaller bore columns are not as “Forgiving”
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Need thicker films here or use guard columns
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Need fast injection
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To create smallest possible injection band
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