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Welcome to the new look for your Restek Advantage!
When we sat down to plan this issue, one of our goals was to
share more chromatography news and better connect with you,
our reader. That’s how our expanded Hot Topics and new Restek
Connections departments came to be. My friend and colleague,
George Fong, is retiring as head of the Florida Pesticide Residue Workshop after almost 50
years. Restek just introduced a new line of secondary columns for GCxGC. Get the latest
scoop on these topics and more over the next 3 pages!
Of course, as always, much of this Advantage highlights the application work of our
Innovations Lab, where we’re lucky to have seasoned veterans working alongside young,
enthusiastic chemists to solve your toughest problems. Looking to determine trace-level
compounds in complex sample matrices like marijuana and urine? You’ll be interested to
read our articles on pesticide and synthetic cannabinoid analysis using both advanced
GCxGC-TOFMS and LC-MS/MS platforms.
LC-MS/MS has revolutionized analytical chemistry, but it still relies on good chromatogra-
phy. Rick Lake and Ty Kahler show you how to get the most selectivity for your LC separa-
tions. Their work employs the hydrophobic subtraction model to define a highly selective
and orthogonal set of 4 USLC™ columns.
Chromatographic column selectivity has always been a Restek forte, and Jason Thomas
proves it yet again using one Rtx®-CLPesticides column pair for 7 GC-ECD environmental
methods. In these cases, chromatographic separation is mandatory for accurate, quantita-
tive work, as the ECD is not a specific detector.
But that’s not all: PLOT columns in process GC, wool in GC inlet liners, large volume split-
less injection... We have something inside for every analyst.
Finally, we also set up a new email address: Use it to let us know
what you think of your new Restek Advantage. I say “ your” because we create this techni-
cal document with your needs and interests in mind. Your feedback will be invaluable for
assembling future issues.
Cheers!
Jack Cochran
Director of New Business & Technology
In This Issue
Restek Connections. . . . . . . . 2–3
Hot Topics. . . . . . . . . . . . 4–5
Technical Articles. . . . . . . . 6–23
Quantifying Synthetic Cannabinoid
Metabolites . . . . . . . . . . . . . . . 6–7
High Quality Analysis of Pesticides in
Marijuana. . . . . . . . . . . . . . . . 8–9
Marijuana Potency Testing by LC or GC. . 10–11
Simplify HPLC and UHPLC Method
Development. . . . . . . . . . . . . . . . . . . . . . . . . .12–13
7 EPA Methods on 1 Column Pair . . . .14–15
Large Volume Splitless Injection with an
Unmodified GC Inlet. . . . . . . . . . 16–17
Extending PLOT Column Technology to
Process GC Analyzers. . . . . . . . . .18–19
Rethinking the Use of Wool With
Splitless GC . . . . . . . . . . . . . . 20–21
Innovators in Chromatography
(Guest Editorial: Dr. Chris Marvin):
Brominated Flame Retardants
by LC-MS. . . . . . . . . . . . . . . .22–23
About Restek Corporation
A leading innovator of chromatography solutions
for both LC and GC, Restek has been developing
and manufacturing columns, reference standards,
sample preparation materials, accessories, and
more since 1985. We provide analysts around the
world with products and services to monitor the
quality of air, water, soil, food, pharmaceuticals,
chemicals, and petroleum products. Our experts
enjoy diverse areas of specialization in chemistry,
chromatography, engineering, and related fields
as well as close relationships with government
agencies, international regulators, academia, and
instrument manufacturers.
Patents and Trademarks
Restek patents and trademarks are the property
of Restek Corporation. Other trademarks appear-
ing in Restek literature or on its website are the
property of their respective owners. The Restek
registered trademarks used here are registered in
the United States and may also be registered in
other countries.
You Have Opinions... And We Want Them.
We chemists are an opinionated bunch, so the odds are good that you have
some thoughts about the Restek Advantage. Love it? Hate it? Want to see
something different in the next issue? Maybe you have a response to one of our
technical articles? Whatever you have to say, let’s hear it! Email your comments to
and you may even see them in an upcoming issue.
Letter from the Bench
Restek Connections
Website : E-Mail : TelNo : 03 9762 2034 . . . in AUSTRALIA