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Column: Rxi®-624Sil MS, 30 m, 0.32 mm ID, 1.80 µm
(cat.# 13870)
Sample: Residual Solvents Class 2 - Mix A (cat.# 36271)
Complete analytical conditions for chromatogram
GC_PH1161 available at
GC_PH1161
Figure 1 Rxi®-624Sil MS columns reliably resolve Class 2 Mix A compounds.
Peaks RT (min.) Conc.
(µg/mL)
1. Methanol 2.281 25.00
2. Acetonitrile 4.009 3.42
3. Dichloromethane 4.313 5.00
4. trans-1,2-Dichloroethene 4.798 7.83
5. cis-1,2-Dichloroethene 7.028 7.83
6. Tetrahydrofuran 7.706 5.75
7. Cyclohexane 8.708 32.33
8. Methylcyclohexane 14.099 9.83
9. 1,4-Dioxane 15.054 3.17
10. Toluene 22.018 7.42
11. Chlorobenzene 26.570 3.00
12. Ethylbenzene 26.837 3.07
13. m-Xylene 27.147 10.85
14. p-Xylene 27.147 2.53
15. o-Xylene 27.927 1.63
Peaks RT (min.) Conc.
(µg/mL)
1. 1,1-Dichloroethene 3.586 0.07
2. 1,1,1-Trichloroethane 8.536 0.08
3. Carbon tetrachloride 9.042 0.03
4. Benzene 9.787 0.02
5. 1,2-Dichloroethane 10.112 0.04
* DMSO interference
Column: Rxi®-624Sil MS, 30 m, 0.32 mm ID, 1.80 µm
(cat.# 13870)
Sample: Residual Solvents - Class 1 (cat.# 36279)
Complete analytical conditions for chromatogram
GC_PH1160 available at
DB-624
Class 1 solvents coelute
Rxi®-624Sil MS
• Baseline resolution
• Easy, reliable quantification
Figure 2 The Rxi®-624Sil MS column provides complete resolution of the USP <467> Class 1 solution components—a result not often
achieved on other G43 columns.
GC_PH1160
Better resolution improves
system suitability pass rates.
When running USP <467> by headspace,
using a smaller bore liner (1 mm) can
improve system suitability pass rates.
Larger bore liners (4 mm) are used with
direct liquid injection because the sample
is vaporized in the injection port and the
liner must be able to accommodate the
solvent expansion volume. In contrast, in
headspace analysis, the sample is vapor-
ized in a vial instead of the injection port,
so a large volume liner is not needed, and
in fact it can be deleterious. In headspace
methods, using a smaller bore liner
reduces band broadening by increasing
linear velocity, allowing faster sample
transfer and improving resolution.
See p. 9 for select 1mm liners.
TECH TIP!
1. Acetonitrile
2. Dichloromethane
GC_PH00912
Resolution passes USP <467> criteria when
using a 1mm liner (red line), but fails if a
4mm liner is used (black line).
Restek carries a full line
of headspace essentials
including screw-thread headspace
vials & magnetic screw-thread
caps, Hot Swap column nuts,
1mm liners, septa, and more!
Visit
for more products and tech tips
Tim Herring, Technical Service Specialist
Rxi®-624Sil MS
min.
5
Website : E-mail : TelNo : 03 9762 2034 . . . in AUSTRALIA