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Comparing Alkyl and Phenyl Phases
CH
3
Si CH
3
O
Si
Conventional
Phenyl
• Retention through
π−π
interactions
• Moderate hydrophobic attraction/retention
• Best for aromatic or unsaturated compounds
• Alternate selectivity to C18
• Retention capacities not as predictable as C18
• Methanol can be used to enhance retention
and selectivity
Characteristics
22
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