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Requirement: analytemust be ionizable
Rapidly growing inpopularity
Positive identificationof analyte
Can discriminate between co-eluting peaks in
selected ionmode
– Reduces resolution required
For best sensitivity, work at pHwhereanalytes
are ionized
– Neutral to basic pH (7-9) for acids
– Acidic pH (3-4) for bases
Detector Selection: Mass Spectrometer
