• No two silica support lots are exactly the same.
• Variationsmay be great frommanufacturer to
manufacturer.
• Simply recommending a column toperform a legacy
separationbasedonphase type (C-8, C-18, etc) is not
enough.
• These factors are very importantwhen selecting
alternate columns formethods under development or
making substitutions.
– ParticleSurfaceArea
– ParticlePoreVolume
– Meanparticle size andDistribution
– MeanParticlePoreSize
– Metals content
