• Silica for analytical chromatography is typically
available in 3, 5, and10µmparticles sizes.
• Themean of these particle sizes and the distribution
ranges varybetweenmanufactures.
• The smaller the particle size the higher the number
of theoretical plates a column canproduce.
• Typically columns producedwith smaller particles
give greater theoretical plates at the cost of higher
pressures.
• Whenusing silica of the same pore volume, smaller
particles produce a linear increase ink’.
