RtxPresentations07 - page 688-689

SampleConsiderations for LC/MS
• TheAnalyteMust Have IonizableGroups
¾
Amines
¾
CarboxylicAcids
¾
Ketones, Aldehydes
• For Best Sensitivity,Work at a pHWhere
theAnalyte is Ionized
¾
Neutral to basic pH (7-9) for acids
¾
Acidic pH (3-4) for bases
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