Restek 2011/12 Chromatography Catalog - page 85

Organic volatile impurities on an Rtx®-5 (Rtx®-G27) column.
www.restek.com 85
GC COLUMNS | APPLICATION-SPECIFIC COLUMNS
Pharmaceut ical
OVI
Retention
Index p.696
CH3
CH3
Si
95%
O Si
5%
O
similar phases
DB-5, HP-5, HP-5MS, Ultra-2, SPB-5, Equity-5,
MDN-5
Rtx®-5 Structure
G27 phase
1. ethylene oxide
2. methanol
3. ethanol
4. diethyl ether
5. 1,1-dichloroethene
6. acetone
7. isopropanol
8. acetonitrile
9. methylene chloride
10. n-hexane
11. n-propanol
12. methyl ethyl ketone
13. ethyl acetate
14. tetrahydrofuran
15. chloroform
16. 1,1,1-trichloroethane
17. carbon tetrachloride
18. benzene
19. 1,2-dichloroethane
20. heptane
21. trichloroethylene
22. n-butanol
23. 1,4-dioxane
24. pyridine
25. toluene
Inj.: Headspace injection of common solvents for pharmaceutical
processing. Prepared to equal about 500ppm in the bulk
pharmaceutical. Samples shaken and heated at 90°C for 15 minutes,
1mL headspace injection.
Oven temp.: 35°C (hold 10 min.) to 100°C @
5°C/min., to 240°C @ 25°C/min. (hold 5 min.)
Inj./det. temp.: 220°C/240°C
FID sensitivity: 1.05 x 10-11 AFS
Carrier gas: helium, 35cm/sec. set @ 35°C
Split ratio: 2:1
2
4 5
1
min. 2 4 6 8 10 12 14 16 18 20 22
8,6,7 9
12,10
11
13 14
15
16
18,17,22
19
20
21
23
24
25
3
Rtx®-5 (Rtx®-G27) with 5m phenylmethyl Integra-Guard® guard column,
30m, 0.53mm ID, 5.0µm (cat.# 10279-126)
GC_PH00260
Organic Volatile Impurities (OVI) Analysis
Rtx®-5 Columns (fused silica)
(low polarity phase; Crossbond® 5% diphenyl/95% dimethyl polysiloxane)
• General purpose columns for drugs, solvent impurities, pesticides, hydrocarbons,
PCB congeners (e.g. Aroclor mixes), essential oils, semivolatiles.
• Temperature range: -60 °C to 350 °C.
• Equivalent to USP G27 and G36 phases.
The 5% diphenyl/95% dimethyl polysiloxane stationary phase is the most popular GC
stationary phase and is used in a wide variety of applications. All residual catalysts and
low molecular weight fragments are removed from the Rtx®-5 polymer, providing a
tight mono-modal distribution and extremely low bleed.
ID df temp. limits 30-Meter
0.53mm 5.00µm -60 to 270/290°C 10279
Solutions For Your Pharmaceutical Analyses
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For our complete listing of Rtx®-5 columns, see page 50.
Website :www.chromtech.net.auE-mail :info@chromtech.net.auTelNo : 03 9762 2034 . . . in AUSTRALIA Mar 2011