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IsoKrom™ Columns
•
Improved column sanitation with a packed bed in (CIP) as well as in a disassembled state.
•
Inexpensive mesh replacement eliminates potential carry-over of sorbent and contaminants.
•
No packing valves blocking the mesh, no stagnant pockets. Uniform unobstructed flow
through the entire bed.
•
Shorter dead-space translates into reduced clearance time (=L
2
), and/or a more thorough CIP.
•
Shortended time for column order delivery. Standard parts (Acrylic tube, Nylon mesh, etc.) are
available on short notice.
•
Due to lower column cost, each purification step can afford a separate dedicated column, with
no need to clean and validate re-packing.
•
No issues with rusting at low pH and/or at high Chloride, EDTA and Citrate concentration.
IsoKrom
™
Columns
•
All wetted parts are either autoclavable, replaceable and/or can be completely
taken apart for thorough cleaning.
•
No metal parts contact the solution: no issues with rusting at low pH and/or at high
NaCl concentration.
Pack sorbent slurry into
precise fixed volume using
sidepacking valve.
Packing valve is retracted
flush with the wall eliminat-
ing dead volume in column.
AVAILABLE SIZES
Tube Volume (L)
ID (cm) at 20- cm bed
9.5
1.4
13.3
2.8
22.9
8.2
33.0
17.1
47.0
34.7
66.0
68.5
79.0
98.0
102.9
166.2
177.8
496.6
238.8
895.5
*
Custom sizes available upon request.
AVAILABLE
ST NDARD SIZES*
“In a multi-product environment, we install
new mesh for each new product run to
prevent carry-over contamination. In contrast
to IsoKrom, frit replacement in other large
columns is expensive, laborious and/or
requires factory service”.
J. Burton Lee, President,
Lee BioSolutions Inc., MO
“Processes have never been this robust with
other systems...[IsoKrom] allows a much
faster cycle time for a column run. Production
personnel really appreciate when different
operators, on different days and with
different batches, can consistently reproduce
the performance”.
Fred Drewe, Ph.D, President,
Drewe Browning Strickler, TX
Other columns employ center
packing valve which creates
dead volume.
Acrylic columns for preparative low-medium pressure
bio-chromatography available from ISO 9000 certified manufacturer