Figure6
USP residual solventClass2MixtureB standard solutiononanRtx®-1301column (G43).
Figure5
USP residual solventClass2MixtureA standard solutiononanRtx®-1301column (G43).
1. methanol
2. acetonitrile (resolution=1.35)
3. dichloromethane
4.
trans
-1,2-dichloroethene
5.
cis
-1,2-dichloroethene
6. tetrahydrofuran
7. cyclohexane
8. methylcyclohexane
9. 1,4-dioxane
10. toluene
11. chlorobenzene
12. ethyl benzene
13.
m
-xylene/
p
-xylene
14.
o
-xylene
GC_PH00910
2. acetonitrile (resolution= 1.35)
3. dichloromethane
9. 1,4-dioxane
GC_PH00911
1. hexane
2. nitromethane
3. chloroform
4. 1,2-dimethoxyethane
5. trichloroethylene
6. pyridine
7. 2-hexanone
8. tetralin
Column:
Rtx
®
-1301, 30m, 0.32mm ID, 1.8µm (cat.# 16092)
Sample:
USP<467>Class 2Mixture B standard solution
(cat.# 36280) in 20mL headspace vial
Inj.:
headspace injection (split ratio 1:5), 1mm split
liner Siltek
®
deactivated (cat.# 20972-214.1)
Inj. temp.:
140°C
Carrier gas: helium, constant flow
Flow rate:
2.16mL/min., 35.3cm/sec.
Oven temp.: 40°C for 20min. to 240°C@
10°C/min. (hold for 20min.)
Det.:
FID@ 240°C
Headspace Conditions
Instrument:
Tekmar HT3
Transfer line temp.:
105°C
Valve oven temp.:
105°C
Sample temp.:
80°C
Sample equil. time:
45min.
Vial pressure:
10psi
Pressurize time:
0.5min.
Loop fill pressure:
5psi
Loop fill time:
2.00min.
Inject time:
1.00min.
Column:
Rtx
®
-1301, 30m, 0.32mm ID, 1.8µm (cat.# 16092)
Sample:
USP<467>Class 2Mixture B standard solution
(cat.# 36280) in 20mL headspace vial
Inj.:
headspace injection (split ratio 1:5), 1mm split
liner Siltek
®
deactivated (cat.# 20972-214.1)
Inj. temp.:
140°C
Carrier gas: helium, constant flow
Flow rate:
2.16mL/min., 35.3cm/sec.
Oven temp.: 40°C for 20min. to 240°C@
10°C/min. (hold for 20min.)
Det.:
FID@ 240°C
Headspace Conditions
Instrument:
Tekmar HT3
Transfer line temp.:
105°C
Valve oven temp.:
105°C
Sample temp.:
80°C
Sample equil. time:
45min.
Vial pressure:
10psi
Pressurize time:
0.5min.
Loop fill pressure:
5psi
Loop fill time:
2.00min.
Inject time:
1.00min.
•
5
•
SYSTEMSUITABILITYCRITERIAMET
